PROTEIN KINASE INHIBITOR LEAD DESIGN BASED ON MARINE BIOPROSPECTING HITS AND OTHER BINDING FRAGMENT DATA

BS0046 Protein kinase inhibitor lead design based on marine bioprospecting hits and other binding fragment data
Interaction studies of protein kinase binding compounds originating from bioprospecting research in Tromsø showed details of inhibition, including atomic resolution 3D structures of two compounds in the protein kinase CDK2. These serve as a foundation for structure based design of potential new anticancer drugs. Also, a newly discovered dimeric form of the MAP kinase p38 could be studied.

Avsluttet 2011

Fylke: Troms
Prosjekttype: Marin bioprospektering
Prosjektsøker: Universitet i Tromsø
Søknadsår: 2011